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RNA Interference Genetic Screen Suggests New Targets for Cancer ...

... RNA Interference Genetic Screen Suggests New Targets for Cancer Therapies, March 29, 2006 News Release - National Institutes of Health (NIH) National Cancer Institute (NCI) EMBARGOED FOR RELEASE Wednesday, March 29, 2006 12:00 p.m.

ET Subscribe CONTACT: NCI Media Relations Branch 301-496-6641 RNA Interference Genetic Screen Suggests New Targets for Cancer Therapies Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have developed a new method to identify genes that keep cancer cells active and that could be potential targets of anticancer therapies.

The method uses RNA interference (RNAi), a technology for silencing genes, to screen cancer cells for genes that, when silenced, cause cancer cells to die or stop dividing.

These genes are essential for the survival of cancer cells and represent potential therapeutic targets, but they might not contain mutations or other alterations typically associated with the disease.

“This method could be used to identify a new class of oncogenes beyond the ones traditionally identified as mutated or otherwise deregulated in cancer,” said lead researcher Louis M.

Staudt, M.D., Ph.D., of NCI’s Center for Cancer Research (CCR).

The method is described in a study to be published online in Nature* on March 29.

“The traditional way of approaching cancer biology is to identify genes in cancer cells altered by mutations or in their functions,” explained Staudt.

“This method identifies additiona...

Spin Control

..."That's the beauty of arguments," he tells his son, "if you argue correctly, you're never wrong." Adapted for the screen and directed by Jason Reitman in his feature debut, Thank You for Smoking is a dark, comedic companion to such recent films as Good Night, and Good Luck and Syriana, both of which recall the politically charged films of the 1970s.

Reitman, whose father, Ivan, directed such classics as Ghostbusters and Meatballs, is clearly a student of cinema, taking as much from his father as from directors like Sidney Lumet, whose films such as Dog Day Afternoon and Network echo in Thank You for Smoking's morally ambiguous mix of politics and humor.

"I am fortunate enough to have a father who is a filmmaker and opened me up to smart films when I was younger," Reitman told WW during a recent phone interview.

"I saw Network, obviously, and I'm sure subversive movies like that, that not only were subversive in their politics but innovative in their filmmaking, had an effect on me.

But when I finally sat down to do Thank You for Smoking, it was just kind of a natural reaction.

It's only since the movie has been finished that I can say, 'OK, I see where I was influenced there.'" advertisement advertisement Although Buckley's b...

Best Places to Work 2006 > What Makes a Company Great

...To root out the cancer, they would hit it with an aggressive, double shot of chemotherapy and radiation.

Abe knew she had to be there for the hospitals trips, for the baffling medical reports, for the exhaustion.

"It was my mother, I had to go," says Abe, an executive assistant at the Hawaii District Navy Exchange and a single mom with one daughter.

Abe had just one week of vacation to burn, then the bills would pile up.

That was reason to worry when her mother's illness was already enough to worry about.

But Abe's employer had a special program for situations like these.

Employees at the Navy Exchange can donate their vacation days to co-workers in need, like Abe.

"I have never worked for a company that had that type of thing and I think it's wonderful, especially when you are in a situation which is pretty sad anyway," says Abe, 43, who returned to work six weeks later, after her mother completed her round of treatment, without missing a pay check.

"It sure takes the burden off." LARGE COMPANY: MARYL GROUP HIGH ROLLERS: For the company's 20th anniversary, Maryl Group took its employees on a 4-day trip to Las Vegas.

The employee first policy at Maryl is paying off for the company, too.

In 2005, Maryl had its best year ever with $115 million in revenues, an 85 percent increase over 2004.

Pictured are Maryl owners Mark and Cheryl Richards, flanked by employees.

Photos by Jimmy Forrest Those types of benefits are part of the reason the Navy Exchange ranks No.

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