Mesothelioma | Mesothelioma

In a Phase II clinical trial designed to evaluate the safety and efficacy of ispinesib in the second-line treatment of patients with either platinum- sensitive or platinum-refractory non-small cell This clinical trial was designed to require a minimum of 1 confirmed partial or complete response out of 20 evaluable patients in a treatment arm to proceed to Stage 2 in that treatment arm.

The trial's primary endpoint is response rate as determined using RECIST criteria.

The best overall responses to date in the platinum-sensitive treatment arm of this clinical trial have been disease stabilization observed in 10 of 20 evaluable patients.

Overall, median time to disease progression was 6 weeks; in the 10 patients whose best response was stable disease, median time to progression was 17 weeks.

The platinum-refractory treatment arm of this clinical trial was completed in 2005; Cytokinetics announced in September of 2005 that the platinum- refractory treatment arm also did not satisfy the criteria for advancement to the next stage of evaluation.

In that treatment arm, disease stabilization was observed in 5 of 20 evaluable patients.

Overall, median time to disease progression was 6 weeks; in the 5 patients whose best response was stable disease, m...

This is not a referendum on our great state motto, 'Live Free or Die.' This is simply a health issue, and a matter of doing what is right for our great state," Sen.

David Gottesman, one of the bill's sponsors said in a statement.

Opponents argue it should be left up to restaurant and bar owners to decide whether to make their businesses smoke-free, noting that a majority already have taken that step.

The House passed the ban last week 189-156.

The Senate is scheduled to vote on the bill on April 6.

If it passes, the smoking ban would become law after 90 days.

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