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Dupuy told Reuters Health.

"This notion has far-reaching implications regarding future therapy for not only We have seen this synergy in other locations as well and have shown it in animal tumor models."Dr.

Dupuy of Rhode Island Hospital, Providence and colleagues treated 24 patients with inoperable NSCLC with CT-guided radiofrequency ablation followed by radiotherapy.

The findings appear in the March issue of Chest.There were no treatment-related deaths or grade 3 or 4 toxicities.

At a mean follow-up just over 2 years, 14 patients had died.

The cumulative survival rate at 2 years was 50% and at 5 years, it was 39%.Ten deaths were cancer-related.

Three patients died of respiratory failure with no evidence of active disease and another died of a cerebrovascular accident.Given these preliminary findings, the researchers just started a national multicenter trial in the hopes of improving survival in this group of patients."SOURCE:Chest 2006;129:738-745.

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