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Cyclacel to Present Preclinical Data on Lead Clinical-Stage Drug ...

...Seliciclib is the lead drug candidate in Cyclacel's pipeline of small molecule cell cycle inhibitors.

The first poster will report findings regarding the mechanism of action of seliciclib and related follow-on compounds in multiple myeloma cells, a hematologic malignancy.

The second poster will report results of in vitro drug combination studies evaluating on non-small cell Details of the poster presentations and related bibliographical citations are as follows: Monday, April 3, 2006 - Novel cyclin dependent kinase (CDK) inhibitors induce down regulation of Mcl-1 and apoptosis in multiple myeloma cells.

Abstract Number: 2069.

Citation: MacCallum, D.E.

et al.

Novel cyclin dependent kinase (CDK) inhibitors induce down regulation of Mcl-1 and apoptosis in multiple myeloma cells.

Proc.

Amer.

Assoc.

Cancer Res.

2006; 47: 2069.

Tuesday, April 4, 2006 - Combination analysis between seliciclib (CYC202; R-roscovitine) and other molecularly targeted anticancer agents in non-small cell Abstract number: 3838.

Citation: Fleming, I.N., et al.

Combination analysis between seliciclib (CYC202; R-roscovitine) and other molecularly targeted anticancer agents in non-small cell Proc.

Amer.

Assoc.

Cancer Res.

2006; 47: 3838.

About Cyclacel Pharmaceuticals, Inc.

Cyclacel is a clinical-stage biopharmaceutical company dedicated t...

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